Background: Psoriasis is a chronic inflammatory skin disease with substantial morbidity. Alterations in

serum albumin, globulin, and albumin–globulin (Albumin-Globulin) ratio have been reported in psoriasis,

but their relationship with disease severity is not well defined in Bangladesh. Objective: To assess the

association of serum albumin, globulin, and Albumin-Globulin ratio with psoriasis severity according to the

Psoriasis Area Severity Index (PASI). Methods: A 12-month cross-sectional study was conducted at the

Department of Dermatology and Venereology, Dhaka Medical College Hospital, including 50 patients with

chronic plaque psoriasis and 50 apparently healthy controls selected by purposive sampling. PASI was used

to categorize psoriasis as mild, moderate,e or severe. Serum albumin, globulin, and Albumin-Globulin ratio

were measured by standard biochemical methods. Data were analyzed using SPSS Version 22 with

Student’s t-test, Chi-square test, one-way ANOVA, and Pearson’s correlation. A p-value <0.05 was

considered significant. Results: Psoriasis patients had a mean age of 44.02±12.15 years with male

predominance (58%). Mean serum albumin (3.77±0.25 vs 4.47±0.30 g/dL, p<0.001) and Albumin-Globulin

Ratio (1.21±0.17 vs 1.55±0.15, p<0.001) was significantly lower in cases than controls, whereas serum

globulin was higher (3.15±0.26 vs 2.89±0.18 g/dL, p<0.001). Among patients, 36% had mild, 44% moderate,

and 20% severe psoriasis. Serum albumin (p=0.002), globulin (p=0.027), and Albumin-Globulin ratio

(p=0.001) differed significantly across PASI categories. PASI correlated negatively with albumin (r=−0.469,

p=0.001) and Albumin-Globulin ratio (r=−0.482, p<0.001) and positively with globulin (r=0.360, p=0.010).

Conclusion: Serum albumin, globulin, and the Albumin-Globulin ratio are significantly altered in Bangladeshi

patients with psoriasis and show strong associations with PASI severity, suggesting potential as a simple

adjunct markers of disease burden.

TBA